T-cells are a primary type of lymphocyte, essential for adaptive immunity, which allows the immune system to remember and target previously encountered invaders. The two main types are: killer T-cells (CD8) which destroy infected or cancerous cells and helper T-cells (CD4) which tell other parts of the immune system to come help fight infections.
CD4 and CD8 comprise up to 75% of lymphocytes and serve as key indicators of immune system health.
Distribution of white blood cells subpopulation in human peripheral blood
Scientists discovered a significant difference in the composition of T-cells, which play a key role in the immune system, between supercentenarian (110 years+) and adults in their 50-80s.
In particular, the share of CD4 T-cells (as a percentage of the total T-cells in the blood) of the supercentarians stood at about 25%. Among average people, the percentage is usually in the single digits.
BENEFITS of GPComplex® DISCOVERED THROUGH TWO DECADES OF RESEARCH
42-day clinical trial involving 240 subjects on the effect of GPComplex® on immune function
growth rate of helper T-cell count: CD4
improvement in helper & killer T-cell ratio: CD4/CD8
growth rate of T-cell count: CD3
Phase II randomized, double blind, placebo controlled, multi-center clinical trial with 240 subjects
To evaluate the effectiveness and safety of GPComplex® in improving immune function in patients with chronic bronchitis
42-day clinical trial involving 480 men and women on the effect of GPComplex® on chronic bronchitis
growth rate of helper T-cell count: CD4
improvement in helper & killer T-cell ratio: CD4/CD8
growth rate of T-cell count: CD3
Phase III randomized, double blind, placebo controlled, multi-center clinical trial with 480 subjects
To evaluate the effect and safety of GPComplex® on increasing CD4, CD4/CD8, and CD3 in patients with chronic bronchitis, and improving major symptoms (cough, phlegm)
4-week observational study involving 32 men and women on the effect of GPComplex® on cancer-related fatigue
Single-arm, single-center, observational study with 22 women and 10 men
To evaluate the effects and safety of GPComplex® on immune function and on major symptoms of cancer-related fatigue
Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Other in vivo and in vitro research studies on GPComplex®
Research | Result |
---|---|
Anti-cancer |
Suppressed tumor growth, activated CD4 and CD8, increased T-cell countsAyeka PA et. al. BMC Complement Altern Med. 2017 |
Anti-cancer |
Exerted anti-tumor effects by affecting gut microbiome compositionZhang X et. al. J Pharmacol Sci. 2018 |
Anti-cancer |
Increased CD3 and CD4 count, promoted T-cell proliferation, enhanced the immune functionTianjin Institute of Pharmaceutical Research |
Cellular immunity |
Improved delayed allergic reaction, enhanced T-cell functionTianjin Institute of Pharmaceutical Research |
Humoral immunity |
Increased antibody (serum IgG level), enhanced humoral immunityTianjin Institute of Pharmaceutical Research |
Anti-bacterial, anti-viral |
Resisted bacterial and viral infections, enhanced immune functionTianjin Institute of Pharmaceutical Research |
Nonspecific immunity |
Increase phagocytic activity, enhanced non-specific immune responseTianjin Institute of Pharmaceutical Research |